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Aldosterone is a hormone that plays an important role in regulating sodium and potassium levels in blood and in controlling blood volume and blood pressure. An Aldosterone test is used to help identify fluid and electrolyte disorders, high blood pressure that is hard to control or occurs at a young age, orthostatic hypotension (low blood pressure caused by standing up), overproduction of aldosterone, and adrenal insufficiency (underactive adrenal glands). High levels are called hyperaldosteronism which can increase blood sodium and lower blood potassium. Low levels are called hypoaldosteronism which can cause low blood pressure, dehydration, low sodium levels, and low potassium levels. Approximately 1-2% of individuals with primary hypertension have primary hyperaldosteronism characterized by hypokalemia (low potassium) and low direct renin.
Liquid Chromatography/Tandem Mass Spectrometry (LC/MS/MS)
Aldosterone concentration varies based on body position and sodium intake. 24-hour urine specimens for aldosterone are an alternative.