Specimen: Blood
Results: 3-5 Business days
Description:
Apolipoprotein A1 (apo A-1) has a specific role in the metabolism of lipids and is the main protein component in high-density lipoprotein (HDL, the “good cholesterol”). Like HDL cholesterol, low Apo-A1 level indicates an increased risk of cardiovascular disease while increased concentrations are associated with reduced risk of cardiovascular disease. Apo A-I may decrease with chronic kidney disease, use of drugs such as: androgens, beta blockers, diuretics, and progestins (synthetic progesterone), smoking, uncontrolled diabetes, and obesity. Increased levels may be seen with the use of drugs such as: carbamazepine, estrogens, ethanol, lovastatin, niacin, oral contraceptives, phenobarbital, pravastatin, and simvastatin, physical exercise, pregnancy, weight reduction, and the use of statins.
Apolipoprotein B (ApoB) is a major component of the very-low-density lipoprotein (VLDL), the intermediate-density lipoprotein (IDL), and the low-density lipoprotein (LDL). ApoB plays a central role in carrying cholesterol and triglycerides from the liver and gut to utilization and storage sites.
Elevated levels indicate an increased risk of cardiovascular disease, familial combined hyperlipidemia, diabetes, hypothyroidism, kidney disease, and the use of certain drugs, such as diuretics, androgens, or beta blockers. Low ApoB levels may indicate hyperthyroidism, malnutrition, Reye syndrome (a rare degenerative brain condition), cirrhosis(scarring) of the liver, and apolipoprotein B deficiency (Bassen-Kornzweig syndrome).
The ratio of these two apolipoproteins correlates with risk of cardiovascular disease.
Methodology:
Nephelometry
Includes:
Apolipoprotein A1, Apolipoprotein B, Apolipoprotein B/A1 Ratio (calculated)
Note: Result turn around times are an estimate and are not guaranteed. Our reference lab may need additional time due to weather, holidays, confirmation/repeat testing, or equipment maintenance.