CICA: Full Array-Cell Science Systems Kit

Note: This is a test kit that will be mailed to you and requires a blood draw. It is your responsibility to arrange the blood draw for your kit.

Fasting Required: No

Special Instructions: Specimen MUST be sent overnight to the lab Monday thru Thursday ONLY. Must be received within 24 hrs (Optimal) to 48 hrs of collection.<br\>

Results: 10-12 Business days once the lab receives the specimen
Note: Result turn around times are an estimate and are not guaranteed. Our reference lab may need additional time due to weather, holidays, confirmation/repeat testing, or equipment maintenance.

Reported: Genetic: HLA typing for celiac disease: HLA-DQ2.5 and HLA-DQ8; Genetic Markers for Crohn’s: ATG16L1 and NOD2; Antibody: Total Serum IgA, tTG (IgA and IgG), DGP (IgA and IgG) & Anti-Saccharomyces Cerevisiae Antibody (ASCA)

Patient Recommendations: Because antibody titers are exposure related, purposeful avoidance of gluten can cause a decrease of serological results. Therefore, the patient’s exposure to gluten containing grains should be considered when interpreting tTg and DGP serology results. For genetic component only: gluten consumption prior to testing would not impact the results. Continue with current eating pattern. No change in gluten consumption is necessary.

For those with a diagnosis of celiac disease, using this test to monitor and assess impact of the gluten free lifestyle on tTg and DGP antibodies, continue to follow the gluten free lifestyle. The strictness of the gluten free lifestyle to prevent celiac disease activity may not be equal for all individuals with the disease. Reports range from a few months to a year or more for the antibody level to go from positive to negative. For those with a diagnosis of celiac disease, please consult your physician to determine if this test is appropriate for you.

Description: The Celiac, IBS, and Crohn’s Array (CICA) evaluates your genetic risk for celiac disease, serum markers associated with active celiac disease process, and genetic serum markers associated with Crohn’s disease.

The CICA is a comprehensive test array that analyzes genetic predisposition, detects specific antibodies, and measures potentially inflammatory cellular reactions all through one simple blood draw.

Celiac disease risk analysis is determined based on the presence or absence of the HLA-DQ genotypes. Both the DQ8 and DQ2.5 genotypes are tested in this array, with the DQ2.5 genotypes representing a much greater risk of celiac disease. Four specific serum antibodies (DGP IgG/IgA and tTG IgG/IgA) are tested due to their high sensitivity and specificity for active celiac disease. The higher the antibody levels, the more likely untreated celiac disease is present. Genetic markers, mutations in the ATG16L1 and NOD2 genes, associated with the Crohn’s disease are tested along with serologic markers for complete assessment. Anti-Saccharomyces Cerevisiae Antibody (ASCA; IgG/IgA) are immune proteins that are frequently present in people who have Crohn’s disease. The presence of ASCA may also reflect increased intestinal inflammation and permeability, including an association with active Crohn’s disease.

This test may be added on to any Alcat food panel at discounted pricing. Please call for pricing.</br\>

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